闭塞性脑血管病脑脊液中多胺水平意义的探讨

Study of the significance of polyamine level in human CSF in occulsive cerebrovasular diseases

本文采用高效液相色谱法检测了１１例闭塞性脑血管病患者及２２例对照者的脑脊液中多胺（腐胺、精胺及亚精胺）的含量。结果表明：精胺、亚精胺改变不大，但腐胺在病人组的脑脊液中含量明显高于对照组。病人组腐胺升高与梗塞灶多少无关，但与梗塞发生的部位有关：病灶位于基底节区者明显高于位于脑其他部位者。腐胺升高主要发生在病后４－６天。本文对上述结果进行了初步探讨，认为腐胺的升高与脑缺血后再灌流期脑损害相关。

Eleven samples of CSF from patients with ischemic cerebral infarction and twenty-two samples as control were detected by HPLC for determination of putrescine,spermidine and spermine.The results showed that the level of putrescine was significantly higher in the patients with ischemic cerebral infarction than that in conrtol group.Though changes of putrescine levels had no relationship with the number of the brain infarctions.It was found that they were related to the locations of the infarctions in basal ganglia,comparing with the other parts of the brain.It suggested that the increase of putrescine in the CSF coincided with the brain damage during postischemic recirculation,but further inverstigations should be made