苯妥英治疗癫痫发作的有效血浓度的探讨

The Approach to the Therapeutic Concentration for Phenytoin in the Treatment of Epileptic Seizures

本文用紫外分光亮度法测定了５８例癫痫病人的苯妥英的有效血浓度，并进行了随访观察。结果显示：苯妥英的有效血浓度为９．６６±６．１１ｍｇ／Ｌ。本文讨论了发作类型对苯妥英的有效血浓度的影响以及成年患者口服苯妥英的起始剂量、有效血浓度与发作间期脑电图和癫痫复发的关系等问题，并提出了建立稳态警界值浓度的可行性。

patients with generalized seizures(GS)or partial seizures(PS)were followed up with determinations of the therapeutic concentrations for phenytoin(TC-PHT)using ultraviolet spectrophotometry,Results showed that the TC-PHT was 9.66±6.11mg/L and there was significant difference between TC-PHTs (P<0.05) when PS was compared with GS.In the study,the relapses were correlated with the initial interictal electroencephalogram(IEEG)(P<0.05)rather than the TC-PHTs,It suggested that the steady-state concentration of 15 mg/L for PHT should be regarded as the warning level of the toxic concentrations.Both types of seizures and initial IEEG shoule be used as the referential index to monitor the TC-PHTs.