普鲁卡因与顺铂并用的放疗效果研究

ENHANCED RADIOSENSITIVITY OF PROCAINE (P) ON CISPLATINUM (DDP) IN EXPERIMENTS CANCER

采用小鼠移植瘤MA737研究了普鲁卡因(P)与顺铂(DDP)并用的放疗效果。8.0Gy/次,1次/间日,7次,总量56Gy照射,P+DDP组瘤体积各时相点均明显低于DDP组(P<0.05～0.001),7/15只鼠肿瘤消失,DDP组为0/15。P+DDP组的ER值分次和一次照射分别为1.55和1.46。P+DDP组的抑瘤率比DDP组提高26％。P+DDP比DDP组的小鼠LD_(50)略大。结果指出,普鲁卡因与顺铂并用提高了放疗效果,毒性略有降低。

Transplanted MA737 tumor in mice was used. Radiotherapy of 56 Gy/2 wk divided in 7 fractions of 8 Gy/48 h was given. The MA737 volume of P+DDP +radiation group was smaller than that of DDP+radiation group (P<0. 05). The regression of MA 737 was observed in 7/15 P+DDP + radiation mice on D9 after irradiation, whereas it was 0/15 in DDP + radiation group. In mice treated with radiotherapy (4. 8-12 Gy/48 h, 3d/wk to a total dose of 12, 24 or 36 Gy) and P (50 mg/kg/48h i. p. ) plus DDP (1. 5mg/Kg/48h i. p. ) 2 hours before irradiation, the ER was 1. 55 in P + DDP+radiation group. In (1. 5 mg/kg/48h i. p. ) mice treated with radiotherpy (20, 30, 40 or 50 Gy), plus procaine (50 mg/kg i. v. ) and DDP (1. 5 mg/kg i. v.) 2 hours before irradiation, the ER was 1. 46. The inhibition rates of MA737 were 84%, 58% and 5% in P + DDP, DDP a0. 72 mg/kg and 10. 20 ± (SE) 0. 38mg/kg, respectively. The LD50(7d) of P + DDP i. p, and i. v. In the normal mice was 10. 60± (SE) 0. 71 mg/kg and 10. 60± (SE) 0. 43mg/kg, respectively. The authors believe that the combination of procaine plus DDP is effecfively radiosensitiz-ing in mice bearing MA737 tumor.