食管癌放疗前后免疫功能的变化与预后

IMMUNCOMPETENCE AND PROGNOSIS IN ESOPHAGEAL CANCER PATIENTS

对92例食管癌放疗前、后进行细胞及体液免疫功能的测定,并随访24～36个月,探讨免疫功能与预后的关系。结果表明:放疗前迟发超敏反应、淋转、IL-2诱导反应和NK活性近期死亡组最差,长期存活组最好,中期死亡组居中;放疗后,近期死亡组细胞免疫功能(仅NK活性除外)进一步明显恶化,长期存活组下降较少,有些指标甚至少有改进。显示食管癌的预后与细胞免疫明显相关,与放疗后的免疫状态一致。IgG、IgA、IgM和C3等体液免疫的变化对预后无意义。

Before and after radiotherapy, cellular and humoral immunocompetence were monitored and clinical follow-up was carried out for 24-36 months in 92 patients with esophageal cancer. The relationship between immunity and prognosis was studid. The results showed: 1. Before radiotherapy, the prognosis of esophageal cancer was found to be related to cell-mediated immunity. The best delayed hypersensitivity, lymphocyte response to PHA and IL-2 and NK activity were found in long-term surviving group. The worst in the group who died in the short term. The median in the who group died in the median term. 2. After radiotherapy, the difference of immunity among these three groups was further expanded. The prognosis was found to be correlated with the post-radiation immunity rather than to the pre-radiation status . 3. The humoral immunity had no prognostic value.