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Preliminary Screening of Non-platinum Complexes of Schiff Bases as Antitumour Agents Using Fluorimetry

Preliminary Screening of Non-platinum Complexes of Schiff Bases as Antitumour Agents Using Fluorimetry
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摘要 Based on the consistency of the in vivo and in vitro interactions of drugs with DNA, a fluorimetric method has been developed as a new in vitro method for preliminary screening of antitumour agents. This method was tested using Schiff bases synthesized from salicylaldehyde with 1-alanine, 1-asparagine and 1-histidine, and complexes of these Schiff bases with Cu(Ⅱ), Zn(Ⅱ), Ni(Ⅱ) and Sn(Ⅳ) as potential antitumour agents.The study of the interaction of the complexes with DNA by a fluorescence probe ethidium bromide (EthBr)-DNA system indicated the parallelism between the binding constants and antineoplastic ratios. The relationship between structure and antitumonr activity was investigated. Based on the consistency of the in vivo and in vitro interactions of drugs with DNA, a fluorimetric method has been developed as a new in vitro method for preliminary screening of antitumour agents. This method was tested using Schiff bases synthesized from salicylaldehyde with 1-alanine, 1-asparagine and 1-histidine, and complexes of these Schiff bases with Cu(Ⅱ), Zn(Ⅱ), Ni(Ⅱ) and Sn(Ⅳ) as potential antitumour agents.The study of the interaction of the complexes with DNA by a fluorescence probe ethidium bromide (EthBr)-DNA system indicated the parallelism between the binding constants and antineoplastic ratios. The relationship between structure and antitumonr activity was investigated.
出处 《Science China Chemistry》 SCIE EI CAS 1993年第2期214-224,共11页 中国科学(化学英文版)
基金 Project supported by the State Education Commission Foundation the National Natural Science Foundation of China.
关键词 fluoreseenee probe in vitro SCREENING of ANTITUMOUR drugs non-platinum complex of SCHIFF base. fluoreseenee probe, in vitro screening of antitumour drugs, non-platinum complex of Schiff base.
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