新生儿鼠伤寒沙门氏菌败血症15例临床分析

NEONATAL SALMONELLA TYPHIMURIUM SEPTICEMIA: CLINICAL ANALYSIS OF 15 CASES

报道1991年11月新生儿腹泻败血症住院患儿15例,血培养全部鼠伤寒沙门氏菌阳性(大便培养亦有6例本菌阳性)。其临床特征为热程长,腹泻重,有不同程度的脱水酸中毒,部分患儿并发硬皮病和高胆红素血症,病程中出现进行性贫血与营养不良。在治疗方面,除抗感染外,尤其注重脱水酸中毒的纠正和支持疗法。本病进展快,且常导致败血症,本次病死率高达60％。全组病例为本自治区某县医院产科婴儿室感染后流行;由亍病情日趋严重而陆续转来我校附属医院。

Reporting 15 referal cases (Nov, 1991) admitted to NMC's Affiliated Hosp. with the diagnosis of seevere neonatal diarrhea (septicemia). These newborn patients were delivered in a county hosp. where they, together with other newborn babies, suffered from an outbreak of severe diarrhea thru crass infection in the nursery-room, the county nurses careless bacterial contamination serving as the transmission factor. Salmonella typhimurium bacilli were found in all 15 cases on blood culture (& 6/15 cases on stool culture) with clinicall features of continuous fever, severe diarrhea, dehydration & acidosis, scleroderma and hyperbilirubinemia were present in some cases. As to therapy, besides aolministration of antibiotics, the authors paid great attention to correct the dehydration & acidosis and to maintain nutriton.