α-细辛脑和苯妥因钠对癫痫患者血清泌乳素和睾丸酮影响的研究

ANALYSIS OF EFFECTS OF α-ASARONE AND PHENYTOIN ON SERUM PROLACTIN AND TESTOSTERONE IN PATIENTS WITH EPILEPSY

用放射免疫法测定30例正常对照组和54例癫痫患者使用α-细辛脑和苯妥因钠前后血清泌乳素和睾丸酮水平。结果发现:①α-细辛脑和苯妥因钠均可导致血清泌乳素和睾丸酮水平升高,②未使用抗癫痫药物前血清泌乳素和睾丸酮与正常对照组比较无统计学意义。

The levels of prolactin and testosterone in the serum were determined by radioimmunoassays in 54 patients with epilepsy and in a control group.Such radioimmunoassays were performed both befone treating the patients with α-asarone or phenytoin and after receiving these drugs for two months.The results showed that α-asarone and phenytoin could increase the levels of prolactin and testosterone in the serum.The increase in the serum prolactin might be due to effects of the drugs on the neurotransmitters(5-hydro xyindoleacetic acid and dopamine).By affecting the hepatic microsomal enzymes or sex hormone binding globulin,these drugs miqhr cause an increase in the serum testosterone.There was no significant differeme in the serum prolactin and testosterone between the control group and the epileptic patients who were not taking any antiepileptic drugs.