男性慢性阻塞性肺疾病和肺源性心脏病患者性激素的改变

CHANGES OF SEX HORMONES IN MALE PA OBSTRUCTIV PLUMONARY DISEASE AND PULMONARY HEART DISEASE

测定了25例男性慢性阻塞性肺疾病(COPD)患者,21例肺心病(PHD)患者和30例正常人对照者的血清黄体生成素、卵泡刺激素、泌乳素、孕激素、睾丸酮和雌二醇的水平,并观察了出现呼吸衰竭的患者治疗前后的性激素动态变化。结果发现,男性COPD和PHD患者存在明显的下丘脑—垂体—性腺功能紊乱,主要表现为睾丸酮水平低下,雌二醇与睾丸酮比值升高,而低睾丸酮血症与缺氧呈显著相关关系。

The contents of the serum luteinizing hormone,follicular stimulating hormone,prolactin,progestogen,testosterone and estradiol of 25 male patients with chronic obstructive disease(COPD),21 male patients with pulmonary heart disease(PHD),and 30 male normal subjects were determined.The above sex hormones were defermined in patients with respiratory failure both before and after treatment.It was found that there were marked disturbances of the hypothalanic—pituitary—gonadal functions in the patients with COPD and PHD.And such disturbances were mainly related to hypoxia.