Preliminary Crystallographic Study on [Lys-B31-NH_2]-Insulin, a Prolonged-Acting Insulin Derivative

1 Introduction The natural insulin in acidic solution is a short-acting preparation of which the diabetics need several injections per day to keep the necessary effect. Therefore, it has been a primary request to search for a long-acting insulin preparation from the beginning of medial me in practice. After the explorations for a long time, a series of prolonged-acting insulin preparations have been used in the treatment of diabetes. But most of them