摘要
1 Introduction X-ray diffraction is the major powerful method to resolve the problems on biological macromolecules in detail, but the large single crystals needed for analysis are usually.difficult to obtain. In contrast to forming three-dimensional(3D) crystals, many proteins can form two-dimensional (2D) crystals easily. There have been several approaches to making 2D crystals. Lipid layer crystallization is a novel 2D crystallization method developed by Kornberg group. Some water-soluble proteins have been crystallized successfully by this method, and it can be possibly used to crystallize some intrinsic membrane proteins. The formed 2D crystals are
基金
Project supported by the National Natural Science Foundation of China.
