甲硝哒唑与庆大霉素联合治疗厌氧菌与兼性菌混合感染的动物实验研究

SYNERGETIC EFFECT OF METRONIDAZOLE AND GENTAMYCIN ON TREATMENT OF MIXED INFECTION BY ANAEROBES AND AEROBES IN MICE

厌氧菌与兼性菌的混合感染及其治疗是目前临床上感染性疾病和抗生素治疗研究领域内的重要问题之一,本文对小鼠混合感染的动物模型甲硝哒唑与庆大霉素治疗结果显示:当脆弱类杆菌10~9CFU/ml大肠杆菌10~8CFU/ml混合感染小鼠6h后,单用甲硝哒唑治疗死亡率为9/10,脓肿率为1/10;单用庆大霉素组死亡率2/10,脓肿率为10/10;两药联用死亡率为2/10,无脓肿发生。两药联用的治疗比较:即时组基本同6h组,而12h开始治疗组死亡率达6/10。脓肿率4/6。提示应及早联合用药以阻断细菌的协同致病作用,控制感染。

The synergetic effect of metronidazole and gentamycin on treatment of mixed infection by anaerobes and aerobes was evaluated in vivo. Results showed 9/10 mice died and 1/10 mice developed subcutaneous abscesses in the group of injection of metronidazole (40mg/Kg) along 6hrs later after mixed infection with B. fragilis and E. coll. The death rate and abscess rate were 2/10 and 10/10 respectively in the group of injection of gentamycin (10mg/kg) along, compared with 2/10 mice died without absecess while combination of the above two drugs. The result also showed that the cure effects were different according to the start time of treatment, The cure effects were equal when treatment started at once or 6hrs later after infection, and higher than that when treatment started 12hrs later after infection.