嗜中性粒细胞核象移动检测在伤寒早期诊断及预后的应用研究

APPLIED STUDY ON DETECTION OF NEUTROPHI CARYOGRAM SHIFT IN EARLY DIAGNOSIS AND PROGNOSIS OF TYPE DFEVER

本文应用嗜中性粒细胞核象移动检测技术以40例非伤寒型败血症为对照组,对50例伤寒病早期中性粒细胞核象移动测定结果同肥达氏反应及血培养结果对比分析,其阳性检出率分别为80%、32%及48%、P<0.001。抗体滴度同中性粒细胞核象移动指标间相关性分析,发病初期呈显著性负相关(r=-0.785、t=8.82、P<0.001);发病极期二者呈显著性正相关(r=0.858、t=11.595、P<0.001);恢复期二者呈显著性负相关(r=-0.901、t=14.393、P<0.001)。即细胞核象异常早于抗体升高之前直到恢复期。伤寒组同非伤寒型败血症组核象移动结果比较有显著性差异(P<0.05)。本法简便快速,早期伤寒检出率高,故可用于伤寒早期预测性诊断及预后观察,同时可用于伤寒与非伤寒败血症早期鉴别诊断。

The detective technique of neutrophi caryogram shift was applied and 40 cases of the non— typhoid septicemias were made as the control group.It was analysed that the detective result of the neutrophi caryogram shift,Widals reaction and blood culture in 50 cases of the early typhoid fever.The positive rates were 80%,32%and 48%,respectively.In the correlation analysis between the anti—body titer and the neutrophi caryogram shift,the initial stage of the typhoid presented remarkable negative correlation(r=-0.785,p<0. 001),the extreme stage presented remarkaoble positive correlation(r=0.858,p<0.001)and the restorative stage presented remarkable negative correlation(r=-0.901,p<0.001).The abnormity of the neutrophi caryogram shift had appeared before the antibody titer rose and disappeared after the antibody titer lowered. There was significant difference(p<0.05)between the results of the neutrophi caryogram shift in typhoid and non—typhoid septicemias.This method was simple and quick and the detective rate for early typhoid was high,s it can be applied to the early diagnosis and prognosis observation of the typhoid and to the early differential diagnosis between the typhoid and non—typhoid septicemia.