胃粘膜菌群与胃疾病发生关系的研究

INVESTIGATION OF STOMACH COLONIES IN HUMAN AND CORRELATION BETWEEN THEM AND GASTRIC DISEASES

本项研究分别对正常人和胃病患者两组进行胃粘膜菌群调查,通过普通培养、厌氧微氧培养、菌种鉴别、H—E 及 W—S 染色组织学检查、胃粘膜 pH 值测定、CPUT 检测诸因素调查后,再对其中36例 SCG患者分抗菌组与非抗菌组进行15天治疗对比观察,结果揭示:①本组在正常人胃粘膜上共培养出19种菌,其中15种为食管与胃粘膜及胃液培养所共有,故认为是一种污染的过路菌,另4种即大肠杆菌、产碱杆菌、厌氧链球菌、脆弱拟杆菌为胃粘膜培养所独有,可能在特定情况下富有致病性。②胃疾病时胃粘膜菌群比例存在严重失调现象。共有菌:独有菌由14:5、需氧菌:厌微氧菌由9:10都增加到24:10,其中粘膜独有菌比例增加尤其明显,但不同胃病间又有差异,并与胃粘膜 pH 值相关。独有菌的增加是胃病的发生原因之一。③胃粘膜独有菌是一种机会致病菌。经抗菌治疗后,症状与组织学改善,菌种减少,菌种比例恢复正常。④活动性胃粘膜炎症时,胃粘膜菌群比例增加,抗菌治疗后又渐恢复正常,其间关系孰因孰果,尚须进一步研究。

Under similar asceptic conditions,specimens were taken from the esophagus,stomach and gastric uice of 10 symptomless volunteers(normal group)and 53 patients(sick group)with the gastric diseases.36 cases t of the 53 ones with CSG were divided randomly into two groups,the antibiotic group(Gentamycin+ ranzolidone)and non—antibiotic one(Sucralfate).The observation had lasted for 15 days.The results showed at among the nomal group,4 bacterial specres had been isolated and they were Coli bacillus,alcaligens bacillus, anaerobic streptococcus and frgilis bacillus.The ratio of the aerobe to anaerobe was 9:10.In the sick group,10 bacterial species had been isolated.The pH values of the gastric juice had little variation.After the antibiotic treatment,the disrupted colony rate of the patients had gradually become normal and the symptoms and the histological changes improved.The difference betweer the stomach CPUT tests and HP culture indicated that besides HP,there was other urease producing bacteria in the stomach mucoa.It can be concluded that there were acteria in the normal gastric mucosa and the imbalance of the colonies related to the gastric diseases.Parts of ese patients needed antibiotic treatmeut.