过氧化酶缺乏的成熟粒细胞与MDS的关系

RELATIONSHIP BETWEEN MYELODYSPLASTIC SYNDROM AND PEROXIDASEDEFICIENT POLYMORPHONUCLEAR LEUCOCYTES

本文观察骨髓增生异常综合征(MDS)32例患者的成熟粒细胞(PMN)的过氧化酶(POX)活性,发现14例(占0.438)有 PMN-pox 缺乏。其中原始细胞增多的难治性贫血(RAEB)和转化中的难治性贫血(RAEBT)的异常发生率最高(分别为0.70和0.60)。本组 MDS 的白血病转化率为0.375。14例伴有 PMN-POX 缺乏的 MDS 中有11例进展为白血病,占转化病的0.786,明显提示 PMN-pox 缺乏是 MDS 白血病转化指示。本研究简单易行,结果可靠,易为病人接受,便于动态观察。有助于 MDS 的早期诊断,分型和治疗。适合在老、少、边地区推广应用。

The action of the peroxidase(POX)in the polymorphonuclear leucocytes (PMN)of 32 patients with myelodysplastic syndrom(MDS)was examined.It was found that 14(43.8%)of 32 cases were peroxidasedeficient in their PMN.The abnormal rate was higher in RAEB and RAEBT groups than that in other groups,which were 70% and 60%,re- spectively.The changing rate of the leukemia was 37.5% among these cases.11 of 14 cases with peroxidasedeficiency developed the leukemia,which suggested obviously that PMN— POX deficiency was a changing index.This method was simple,practical,correct and easy to be accepted by the patients.It will be helpful to the early diagnosis,subtype and treatment of MDS.