男性慢性肝病患者基础血清催乳素的测定及其临床意义

The Determination and Its Clinical Significance of Basal Serum Prolactin of Male Chronic Heptopath

应用RIA法检测了62例慢性肝炎和肝硬化患者基础血清催乳素(PRL)和雌二醇(E_2)的浓度。结果表明慢性肝炎和肝硬化血清PRL水平均高于正常,其中尤以肝性脑病患者最为显著。本文认为其增高的机制可能与支链氨基酸减少或支/芳氨基酸比例失调和下丘脑假性神经介质积聚有关,而与血清E_2水平无恒定关系。

The concentrations of basal serum prolactin(PRL)and estradiol (E_2) of 62 cases of chronic hepatitis and hepatocirrhosis were determined by RIA method. The results showed that the serum PRL levels ip both chronic hepatitis and hepatocirrhosis were higher than that in normal person,especially markedly higher in hepatic encephalopathy. The author suggests that the mechanism of higher PRL level may be related to the decrease of branched-chain amino acid or imbalance of the ratio of branched-chain amino acid and aromatic amino acid,and the accumulation of hypothalamus false neurotransmitters, but no constant relation to serum E_2 level.