吡喹酮栓剂治疗动物血吸虫病的实验研究

SUPPOSITORY RECTAL-PRAZIQUANTEL FOR TREATMENT OF RABBITS AND MICE INFECTED WITH SCHISTOSOMA JAPONICUM

本项实验研究采用吡喹酮栓剂治疗家兔及小鼠实验性日本血吸虫病,结果证明在相同剂量条件下,吡喹酮栓剂组的平均减虫率优于吡喹酮口服组。肝脏虫卵肉芽肿检查亦以吡喹酮栓剂组较小,病变较轻。研究证明,吡喹酮肛栓投药是治疗血吸虫病的又一有效途径。

Rabbits and mice infected with Schistosoma japonicum were treated with one sigle suppository rectal-praziquantel. The results showed that bisexual worm reduction rates were obviously higher in suppository rectal-praziquantel groups than those with single-dose oral praziquantel groups. Histopathologic examination also showed that liver egg granulomas in suppository rectal-praziquantel groups were less in number and smaller in size than those in single dose oral praziquantel groups. It is suggested that suppository rectal-praziquantel for treatment of Schistosomiasis japonicum is an efficient method.