摘要
One hind leg(about 7% TBSA)of a rat was scalded and the changes of thereduction-oxidation state and protein degradation in the soleus muscle were observed inthe 72nd h after scalding both in vitro and in vivo.It was found that the lactate/pyruvate(L/P)and malate/pyruvate(M/P)ratios in the soleus muscle were significantly lower andthe protein degradation rate significantly higher in the scalded rats than those in the controland in the unscalded legs.After the addition of insulin to the medium,significant eleva-tion of L/P and M/P ratios and reduction of the protein degradation rate were observedin the soleus muscle.These findings suggest that there is a good correlation between thechanges of the reduction-oxidation and the protein degradation rate in the cytosol of thesoleus muscle after scalding in rats.
One hind leg(about 7% TBSA)of a rat was scalded and the changes of the reduction-oxidation state and protein degradation in the soleus muscle were observed in the 72nd h after scalding both in vitro and in vivo.It was found that the lactate/pyruvate (L/P)and malate/pyruvate(M/P)ratios in the soleus muscle were significantly lower and the protein degradation rate significantly higher in the scalded rats than those in the control and in the unscalded legs.After the addition of insulin to the medium,significant eleva- tion of L/P and M/P ratios and reduction of the protein degradation rate were observed in the soleus muscle.These findings suggest that there is a good correlation between the changes of the reduction-oxidation and the protein degradation rate in the cytosol of the soleus muscle after scalding in rats.
