安宫牛黄丸脑水肿家兔心肺肾病变的影响

Effect of Bezoav Bolus for Resurrection on Pathological Changes of Heart, Lung and Kidney in Rabbits with Cerebral Edema

用病理学方法检查脑水肿家兔心、肺、肾的变化,同时观察中成药安宫牛黄丸对这些脏器的影响。结果发现:造型组在发生脑水肿的同时心、肺、肾组织均出现血管扩张充血,组织细胞变性,上皮细胞脱落等改变。肺、肾小血管和毛细血管内形成广泛微血栓。而用药组则心、肺、肾病变较轻,肺内微血栓体积较小且数量少,与造型组有非常显著差异。提示安宫牛黄丸对百日咳杆菌产生的毒性有缓解作用。

Pathological methods were used to observe changes of heart, lung and kidney in rabbits with cere- bral edema and effect of Bezoar Bolus for Resurrection on these organs. The results showed that in the untreated group dilation and congestion of the blood vessels, degeneration of histiocytes and exfoliation of epithelial cells occurred in all these organs and extensive microthrombi were fromed in the small blood vessels and capillaries in the lung and kidney. In the treatment group, homever, the pathological changes of the heart, lung and kidney were milder and the microthrombi in the lung were smaller in size and number, which is significantly different trom the untreated group. This suggests that Bezoar Bo- lus for Recurrection can relieve the toxic effect produced by Bordetella pertussis.