黄蜀葵花对家兔肾炎模型免疫功能的影响

Effect of The Flower of Abelmoschus Manihot on Immunity of Rabbit Nephritis Model

观察黄蜀葵花对家兔体系膜增生性肾炎(MsPGN)模型B细胞及T细胞免疫功能的影响,结果显示药物组CIC水平下降,红细胞免疫复合物花环率明显高于病理对照组(P<0.01),且二者呈高度显著性正相关(P<0.01);OKT_3、OKT_8明显高于病理组(P<0.01);免疫荧光及电镜显示药物组系膜区免疫复合物沉积明显减少,表明该药具有提高红细胞免疫粘附力,促进CIC的转运与清除,从而减轻CIC介导性肾损伤的作用,且可能有调节细胞免疫功能、抑制体液免疫反应程度的药理效应。

Observation was carried out on the effect of the flower of Abelmoschus manihot on the immunity of B—cells and Tcells of rabbit nephritis model. The results showed that this drug can increase erythrocyte immune adherence, promote the activity of CIC and therefore reduce the sedimentation of CIC in the glomerulus.