影响外周T细胞淋巴瘤疗效及预后的因素研究

Treatment Response and Prognosic Factors of Peripheral T Cell Lymphoma

目的探讨影响外周T细胞淋巴瘤(PTCL)疗效和预后的因素。方法回顾性分析2005年10月—2008年1月我院收治的30例PTCL患者的临床资料,评价其治疗效果及其预后因素。结果 30例PTCL患者,完全缓解(CR)6例(20.0%),中位疗程2(1～4)个周期获得CR,部分缓解(PR)7例(23.3%),总有效率(OR)为43.3%。无骨髓侵犯与有骨髓侵犯患者CR率比较,差异有统计学意义(χ2=4.43,P<0.05)。1、2、3年的总生存率分别为66.7%、53.3%及40.0%。中位生存时间16.5个月。患者的一般状况(ECOG)评分、B症状、国际预后指数(IPI)评分、骨髓侵犯、乳酸脱氢酶(LDH)水平、血清糖类抗原125(CA125)水平、β2微球蛋白(β2-MG)水平与3年生存率有关(P<0.05)。结论 PTCL是一类预后不良的疾病,治疗效果差。骨髓侵犯是影响近期疗效的重要因素。患者的ECOG评分、B症状、IPI评分、骨髓侵犯、LDH水平、CA125水平、β2-MG水平是影响患者预后的重要因素。

Objective To investigate the treatment response and prognostic factors of peripheral T cell lymphoma（PTCL）.Methods Clinical data of 30 cases of PTCL in our hospital from October 2005 to January 2008 were retrospectively analyzed with the treatment response and prognostic factors evaluated.Results Of all the patients,complete remission（CR） rate was 20.0%（6/30）,with a median treatment course of 2（1~4）cycles.Partial remission（PR） rate was 23.3%（7/30） and overall response（OR） rate was 43.3%.Patients with bone marrow infiltration have a lower complete remission rate and a worse recent curative effect compared with patients without.（χ2=4.43,P0.05）.The 1-year,2-year and 3-year overall survival rates were 66.7%,53.3% and 40.0% respectively.Median survival time was 16.5 months.ECOG scores,B symptom,International Prognostic Index（IPI） scores,bone marrow infiltration,level of lactate dehydrogenase（LDH）,carbonhydrate antigen 125（CA125） and β2-micro-globulin（β2-MG） were associated with 3-year overall survival rate（P0.05）.Conclusion PTCL is one of the diseases with poor prognosis and treatment response.Bone marrow infiltration is an important factor affecting the recent curative effects.ECOG scores,B symptom,IPI,bone marrow infiltration,level of LDH,CA125 and β2-MG are important prognostic factors.