硫酸铝钾对小鼠肝损害的实验研究

EXPERIMENTAL STUDY OF MICE LIVER DAMAGED BY ALUMINUM POTASSIUM SULFATE

本文主要观察硫酸铝钾——饮用水净化剂引致小鼠肝酶组化,超微结构和组织结构的变化。动物30只,分为正常组、硫酸铝钾大、小剂量组。实验结果:硫酸铝钾10mg/kg/日(大剂量组)与5mg/kg/日(小剂量组)动物用药10天、80天均可使肝SDH酶活性降低;肝细胞线粒体肿胀、嵴断裂和溶解。在光学显微镜下用药80天后大部分肝细胞肿胀,胞浆疏松淡染、肝小叶内可见呈小灶状分布的炎性细胞浸润,主要为淋巴细胞及浆细胞,门管区偶见少许炎性细胞,但肝小叶和门管区未见结缔组织增生。为此,硫酸铝钾作为净水剂,不宜用量过大。

This study presented histochemical, ultrastructural and histological changes induced by aluminum potassium sulfate in 30 mice (20—25g), which were divided into three groups, Group A was normal control. Group B and C were fed with a solution containing aluminum potassium sulfate, the dosage of which was 5mg or 10mg/kg/day for ten or eighty days respectively.The experimental results showed that the activity of SDH were decreased in these two groups. Under electron microscope, the degenerative changes of hepatic cells were found in these two groups. Mitochondria appeared swelling, mitochndria crista broken and dissolved. Under light microscope, most hepatic cells in group C were swollen, cytoplasma become loosen and stained light in colour. In hepatic lobules, as well as in portal area there were some inflammative cells, mainly lymphocytes and plasma cells were seen. However, there was no multiplication of connective tissue in hepatic lobules or portal area.