11～14岁儿童的气道高反应性的临床意义

Measurement of Bronchial Responsiveness in Elder Children

采用组织胺气管激发试验对11～14岁儿童1507例作气道反应性研究。结果:11～14岁儿童的PEF与身高显著相关,随身高增长PEF增大。男女各年龄组激发试验时通气功能的改变无显著差异。1507例儿童中气道高反应性(BHR)发病率为4.0%,现患哮喘儿童的BHR发病率及严重程度显著高于曾患喘息儿童,有喘息史者亦显著高于无喘息史儿童。激发试验中未见严重不良反应。支气管激发试验敏感性高,安全,操作方便,适用于年长儿童气道反应性的临床及流行病学调查。

Histamine bronchial provocation test was performed to detect the bronchial responsiveness in 1507 students aged 11～14 years, It was shown that the peak flow value was significantly related to the height of children. No significant differences were found amoung different aged groups in the changes of ventilation function after bronchial provocation test. The prevalence of bronchial hyperresponsiveness(BHR) was 4.0%. The izrevalence and the severity of BHR in children with current asthma was significantly higher than those with post asthma,and the prevalence and the severity of BHR in children with wheezing history was also significanty higher than those without wheezing history. No severe side effects were found during and after bronchial provocation test. Histamine bronchial provocation test is suitable in evaluating the bronchial reactivity of elder children in clinical and epidemic research since its sensitivity, safty and easy to perform.