涎腺肿瘤中核仁形成区的定量分析

Nucleolar Organizer Regions in Salivary Gland Tumors

本文采用AgNOR技术对多种涎腺肿瘤的核仁形成区(NOR)进行定量分析和形态观察。结果表明,涎腺肿瘤中的AgNOR计数均值基本上与肿瘤的生物学行为相平行,即恶性肿瘤的计数值高于良性肿瘤,具有侵袭行为的交界肿瘤(混合瘤)高于涎腺良性肿瘤。统计学分析各组间有显著性差异。粘液表皮样癌和腺样囊性癌各病例均值离散度较大。提示AgNOR技术可作为涎腺肿瘤鉴别诊断和分型分组的重要辅助手段。

A silver colloid technique used to visualize nucleolar organizer regions associated protein (AgNOR) has been applied to 83 cases of salivary gland tumors. The results showed that the AgNOR count increased in grades from adenolymphoma through pleomorphic adenoma to malignant tumors and the AgNOR count and morphogenesis seemed to correlate with the biological behavier. It is suggested that the argyrophilic staining technique might help to diagnose and prognose for salivary gland tumors.