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系统性红斑狼疮病人补体C_4别型的检测

Allotype of C_4 Detected in patients with Systemic Lupus Erythematous
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摘要 本文对65例系统性红斑狼疮病人的补体C<sub>4</sub>别型进行了检测,并与98例正常人作了对照,结果是:SLE病人的C<sub>4</sub><sup>*</sup>AQ<sub>o</sub>和C<sub>4</sub><sup>*</sup>BQ<sub>o</sub>频率明显增高,C<sub>4</sub><sup>A</sup><sub>3</sub>频率明显下降。(P【0.001) The allotype and gene frequence of C, have been detected in 65 patients with systemic lupus erythemtous and in 98 healthy controls. The result showed: C; AQo and C,* BQo gene frequcnces were increased and c4*∧3 gene frequence decreased. The statistics were significantly different.
出处 《广州医学院学报》 1993年第2期66-67,共2页 Academic Journal of Guangzhou Medical College
关键词 全身性红斑狼疮 HLA 补体 C<sub>1</sub> 别型 SLE HLA C, allotype
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参考文献7

  • 1赵修竹,张文杰,田延武,吴锋,张莉,姜晓丹,孙曾拯,胡长发,王伟蓁,甘霖.全身性红斑狼疮病人补体第四成分(C4)的别型变化及C4QO的检出频率[J]科学通报,1988(13).
  • 2John D. Reveille,Frank C. Arnett,Raymond W. Wilson,Wilma B. Bias,Robert H. McLean.Null alleles of the fourth component of complement and HLA haplotypes in familial systemic lupus erythematosus[J]. Immunogenetics . 1985 (4)
  • 3Zhang WJ,et al.Allotyping on plasma or serum, application to routine laboratories. Human Immunology . 1988
  • 4Mauff,G,et al.statement of the nomenclature of Human C, Allotypes. Immunobiol . 1983
  • 5Reveille,JD. et al.Null alleles of the fourth component of complement and HLA haplotypes in familial systemic lupus erythematous. Immunogenetics . 1985
  • 6Sjohdm,AG. et al.lymphocyte alloantigens associated with systemic lupus erythematous. clin Genet . 1985
  • 7Fielder,AHL. et al.Family study of the majar histocompatibity complex in patients with systemic lupus erythematous: importance of null alleles of C, A and C, B in determining disease susceptibility. British Medical Journal . 1983

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