鳞癌相关抗原监测肺鳞癌手术疗效的临床意义

CLINICAL EVALUATION OF SCC AG IN MONITORING SURGICAL THERAPEUTIC EFFECTS FOR SQUAMOUS CELL LUNG CANCER

用免疫放射量度分析法检测了48例肺鳞癌病人手术前后的血清鳞癌相关抗原(SCC Ag)水平.29例行根治性切除术,14例行姑息性切除术,5例行剖胸探查术.在根治性切除术后,异常升高的SCC Ag在72小时内降至正常水平,差异有显著意义(P<0.001).姑息性切除术后,SCC Ag常下降,仍高于正常值;剖胸探查术后,SCC Ag无明显改变.本研究证实SCC Ag对手术疗效反应敏感,是一种监测肺鳞癌病人手术疗效的很有价值的肿瘤标志物.

The serum lenels of squamous cell carcinoma associated antigen (SCC Ag) were measured prooperatively and postopera-tively by immunoradiometric assay in 48 patients with squamous cell lung carcinoma, of them 29 patients received curative resection, 14 patients palliative surgery, 5 patients exploratory thoracotomy- Elevated prooperative levels were found to drop dramatically to normal within 72 hours ,with significant difference (P<0. 001); In patients with palliative resection, the elevated levels declined but usually remained above the normal range; with exploratory thoracotomy, the levels showed little variation. The study proved that SCC Ag responded well to surgical therapeutic effects, it was considered to be a very useful tumor marker in monitoring surgical therapeutic effects for squamous cell iung carcinoma.