数种中药对迟发型变态反应的影响

Effects of some kinds of crude drugs on the delayed type hypersensitivity reactions in mice

本研究观察了苦参、地肤子、赤芍和鸡血藤对迟发型变态反应(DTH)的影响。结果发现,在抗原致敏后至攻击前(DTH的诱导相)期间给药,对2、4-二硝基氯苯(DNCB)或 2,4,6-三硝基氯苯(CP)所致的接触性皮炎、SRBC所 致足跖反应的诱导相及在抗原攻击后(DTH的效应相)给药,鸡血藤有较明显或显著的抑制作用;其它三味中药仅在抗原攻击后给药对PC所致的DTH有较强的抑制作用,表明这三味中药主要是抑制致敏T淋巴细胞释放淋巴因子及其以后的炎症过程。

In the present study,the effects of Radix Sophorae Flavescentis, Fructus Kochiae, Radix Paeoniae Rubra and Caulis Spatholobi (CS) on the declayed type hypersensitivity (DTH) reactions were examined. As the result, except for CS which showed a distinct inhibition against dinitrochlorobenzene or picryl chloride(PC)-induced contact dermatitis, no obvious influence was observed in other 3 drugs, when given during the period from the antigen sensitization to the challenge (in the induction phase of DTH). CS also inhibited the induction phase of sheep red blood cells-induced footpad reaction. Howe-er, the administration of all the drugs after the antigen challenge(in the effector phase of DTH) remarkably suppressed the PC-induced DTH. These results suggest that CS could inhibit both induction and effector phases of DTH, and the others show the inhibitory activity mainly through affecting the release of lymphokines from sensitized T cells and the following inflammatory process.