晚期尿毒症血透病人血小板聚集功能变化及其意义

Change of Platelet Accumulating Function in Patients with Advanced Uremia and Its Significance

本文报告30例晚期尿毒症患者血透前、首剂肝素化后及血透后24h检测了血小板1min和5min聚集率。结果显示,尿毒症患者血小板1min及5min聚集率均显著低于正常,首剂肝素化后有显著提高,血透后24h较血透前有明显改善。上述结果表明:尿毒症患者血小板聚集功能低下,这可能是该类患者常有出血倾向的主要原因之一;作为抗凝药物的肝素,对血小板功能有活化作用;血透能改善这类患者的血小板功能,是防治其出血倾向的有效措施。

Platelet accumulating rates for one minute and five minutes were measured before blood dialysis, after first-dosage heparinization, and 24 hours after the dialysis in 30 patients with advanced uremia. The results showed that: platelet accumulating rates for one minute and five minutes were significantly lower in these patients than in normal persons. They raised after first—dosage heparinization, and improved at 24 hours after the dialysis. It is concluded that: a low platelet accumnlating function exists in patients with uremia and it may be a main explanation why there was at times a bleeding tendency in these patients. Heparin, an anticoagulative drug, can activate platelet funtion, and blood dialysis can improve platelet function of these patients and may be effective method of preventing them from bleeding.