摘要
The changes of somatostatin (SS)—like immunoreactive cells and morphology were observed inthe models of ligation of right MCA and bilateral ligation of CCA respectively.The resultsshowed:(1) a decline of SS immunoreactive nerve cell profiles in right cerebral cortex after 3hligation of MCA as compared with left cerebral cortex and sham operated group,while no sig-nificant difference was found between RSM-treated and saline-treated groups;(2) selectiveischemic cell changes in cerebral cortex,hippocampus and caudate nucleus after 3h ligation ofCCA.The changes included shrinkage and condensation of perikaryon,nuclear pyknosis,cytoplasmic eosinophilia in some neurons.The ischemic changes were more severe insaline-treated group than RSM-treated group.The experiments indicated that the selectiveischemic cell changes could be improved by RSM,suggesting that treatment to modulate SSmetabolism may be indicated after ischemic insults.
The changes of somatostatin (SS)—like immunoreactive cells and morphology were observed in the models of ligation of right MCA and bilateral ligation of CCA respectively.The results showed:(1) a decline of SS immunoreactive nerve cell profiles in right cerebral cortex after 3h ligation of MCA as compared with left cerebral cortex and sham operated group,while no sig- nificant difference was found between RSM-treated and saline-treated groups;(2) selective ischemic cell changes in cerebral cortex,hippocampus and caudate nucleus after 3h ligation of CCA.The changes included shrinkage and condensation of perikaryon,nuclear pyknosis, cytoplasmic eosinophilia in some neurons.The ischemic changes were more severe in saline-treated group than RSM-treated group.The experiments indicated that the selective ischemic cell changes could be improved by RSM,suggesting that treatment to modulate SS metabolism may be indicated after ischemic insults.
