Total Synthesis of Chilobolide A

Chilobolide A(1) is one of cembranolide natural products isolated from the soft coral Lobophytum s. p. from the South China Sea. It contains a 14-membered ring, an α,β-unsaturated γ-lactone ring, an epoxide fragment and five chiral carbon atoms in the molecular skeleton. These kinds of compounds have character with Michael acceptor’s and most of them have cytotoxicity and antitumour activity. Because of its low content