摘要
Scientists have long been interested in the synthesis and medical use of 4’-thionudeosides. However, their effect on DNA synthesis has not been well studied. In order to study their bioactivity and explore new applications, we have synthesized 4’-thio-2’-deoxythymidine-5’-triphosphate (T’TP). The experimental results obtained in our lab showed that T’TP is a strong inhibitor of DNA polymerase, and the inhibition is highly specific. These prbperties indicate the potential of T’TP used for antitumor and antiviral agents as well as for the terminator in DNA sequencing.
