不同人群血液流变学和凝血纤溶的“脱适应”变化的观察

OBSERVSTION OF HEMORRHEOLOGY COAGULATIVE AND FIBRINOLYTIC DE—ADAPTED RESPONSE ON DIFFERENT POPULATION

本文对长期居住在海拔2260m的三组不同人员(自身队员、60岁以上老年人、西宁退休人员)、先后进入到平原的苏州、上海地区、在其前后进行了血液流变学、血凝机制、血小板粘附率、体外血栓形成、纤溶酶原等改变,结果表明,长期移居高原的人,进入到平原后,虽然时间短,但上述指标已有改变,表现在HCT、ηb的下降,高凝状态改善,纤溶亢进减轻,这是“脱适应”的变化,是对氧供环境正常后的一种“再适应”改变,但有些指标改变不明显,除因返回平原时间短外,老年人与中青年人比较,其“脱适应”变化较迟钝。

We measured hemorrheology,eoagulative and fibrinolytie changes on different population at dif ferent altitude when they entered plain from long habitated high altitude. The subjects were divided into 4 groups. ①Normal adults(NA):37 cases aged from 18 to 53 coming from Xining.②Senile group (SG):11 cases aged from 60 to 70 coming from Xining. ③Emigrated group(EG):55 cases aged from 42 to 75. They had habitated in Xining for 20 years, and had retarned to sea level for at least half a year. ④The coutrol group were lowlander. The studies were done in Xining and/or,after they arrived sea level. Hemocrit decreased on both NA and SG after they entering phin(P<0.01). EG was higher than native control(P<0.01). Ergthrocyte sediment ratio and phsminogen increased on both NA and SG after they entering plain. EG was the same as control. Recalcification/time were shorter at least 30 seconds on NA and SG. Partial thrombophstin time was shorter at least 3 seconds on SG. AG was the same as control. Platelet adhesiveness test was reduced on NA. The results showed that all the indice we measured were changed after the snbjects who used to live on high altitude entered plain. It indicated that those differences cannot return to the level of lowlanders within a short period. These characters may take long time to recover or to exist forever.