高原COPD遗传度及血清α_1-G水平分析

STUDY OF HERITABILITY AND LEVEL OF α_1—G FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT HIGH ALTITUDE IN QINHGAI PLATEAU

本文报告了青海高原中老年人COPD遗传、患病率以及α_1—G的研究结果。表明青海高原COPD遗传度的加权平均值为29.63％±6.98％,其遗传方式符合多基因遗传,并说明在高原低氧地区与遗传因素相比环境因素对COPD的发病起主导作用;α_1—G在COPD缓解期的水平明显于正常人组(P<0.05),这说明α_1—G的缺乏对COPD,尤其对肺气肿的发病有关。提供了在高原低氧环境中COPD遗传情况的资料。

The results of heredity and the morboiditty rate and α_1—G level of elderly and middle—aged patients of COPD were reported in Qinghai plateau the results showing the weighted mean of heritability of COPD is 22.63%±6.98, according with the way of multigenic inheritance It seemed that envir omental factor still played an important role in COPD at high altitude in Qinghai. The level of α_1—G in stability period of COPD is lower than that in normal people(P<0.05). Analysis of the low level of α_1—G in COPD might permit us to consider relating to genesis of emphysema. The findings are importantt in studying The role of genetic factor in the pathogenic mechanism of COPD at high altitude.