Norplant皮下埋植避孕法对血小板、凝血、抗凝和纤溶系统影响的初步研究

Preliminary Study of the Effect of Norplant on Platelet, Blood Coagulation Anticoagulation Activity and Fibrinolysis.

本文研究Norplant皮下埋植避孕法对血小板、凝血、抗凝和纤溶系统的影响,结果表明:使用Norplant各组与对照相比,虽然V:C下降有显著意义,VWF在使用36～42个月组下降亦有显著意义,但仍在正常值范围内,其它各参数未见有统计学意义的变化。提示Norplant长期使用无高血凝倾向。

In order to study the effect of Norplant on platelet, blood coagulation, anticoagulation activity and fibrinolysis, a cross-sectional study was undertaken. Ninety-two women using Norplant were divided into 3 groups depending on the duration of Norplant used,(i. e. 6-35months, 36-59month, ≥60months). Thirty healthy women never using IUD or oral contraceptives were the controls. The study was comprised of the measurement of platelet count and aggregability, prothrombin time(PT), coagulation factorsⅤ. Ⅶ. and Ⅸ, activity factorⅤ, factorⅦ, factorⅧ, factorⅨ), von Willebrand factor(vWF), antithrombin Ⅲ antigen(AT-Ⅲ), fibrinogen and fibrinogen degra dation products(FDP). The results showed differences between each Norplant using groups and the control group: factorⅤwas significantly decreased; vWF was also significantly decreased during 36—42 months of administration, but both were in normal ranges. Other parameters were not changed significantly. This indicated that long-term use of Norplant is safe.