摘要
610例停经≤49天早孕妇女分为5个治疗组,分别用米索前列醇(简称米索)0.2~0.4mg口服,或卡PG0.5mg肌注,或PG05 1mg阴道给药与国产米非司酮100mg(25mg,Bid×2天)或150mg(25mg,Bid×3天)配伍抗早孕。另选择了110例停经】49天的早孕妇女口服米非司酮+卡PG0.5mg肌注,比较6个治疗组之间的效果。结果:完全流产率波动于87.9%~94.6%,不完全流产率1.8%~5.2%,失败率1.6%~6.9%。各组间效果无明显差别(P】0.05)。本研究结果提示:米非司酮的最低有效剂量可为100mg;米非司酮与米索配伍抗早孕是目前较理想的方法;在医生的指导和管理下国内抗早孕的孕天可提高到停经56天。
Seven hundred twenty cases of eraly pregnancy were terminated with low doeses of RU486 in combination with different prostaglandins. Among them, 610 women with amenorrhea≤49 days were divided in to 5 regiments, such as RU486 100mg or 150mg in combination with misoprostol 0.2-0.4mg per oral, or carbprostol(dl-15 methyl prostaglandin F_(2a)) 0.5mg I. M. or PG05(d1-15 methyl PGF_(2a) methyl ester 1mg intravaginal insertion. Another 110 women with amenorrhea>49 days were terminated by RU486 100mg in combination with intramuscular injection of carboprostol 0.5mg. The clinical efficacy and side effects of the six combination regimens were studied. The results showed that complete abortion rates waried between 87.9-94.6%, incomplete abortion rates were 1.8-5.2% and the failure rates were 1.6—6.9%. There was no significant difference among the six regimens.(P>0.05) This study showed that the lowest effective dose of RU486 used in combination with prostaglandin was 100mg(25mg Bid for 2 days) and this medical induction method can be used up to 56 days pregnancy under the monitoring in hospital. The results also showed that oral PGE, analogue, misoprostol, would be an ideal prostaglandin in combination with RU486 for termination of early Dregnancy.
出处
《中国计划生育学杂志》
1993年第6期336-339,382,共5页
Chinese Journal of Family Planning