食管鳞状上皮癌生长方式的体视学分型研究

STUDY ON STEREOLOGICALLY TYPING THE GROWTH PATTERNS OF SQUAMOUS CELL EPITHELIAL CARCINOMA OF THE ESOPHAGUS

对91例术后存活5年和96例死于术后1年内的食管鳞状上皮癌生长方式的体视学研究结果发现,癌巢表面积密度(Sv值)>2.50的78位病人中92％死于1年内.Sv值≤2.00的72位病人92％生存5年。提出癌肿生长方式的体视学分型:Sv值>2.50为危险型;Sv值≤2.00为安全型;Sv值介于两者之间为交界型。

Morphologic and stereologic studies were made on 91 patients (GA) with squamous cell epithelial carcinoma of the esophagus who survived for over 5 years postoperatively and on 96 patients (GB) who, during the same period of time, died withein 1 year after operation for such a disease, using the M42 point calculation method of the multifunctional system to find out the Sv and Vv of cancer nests. Results were as follows:①The Sv reflected the rate of cancer metastasis to the lymph nodes (RCMLN). Specifically, in GA. the Sv>2. 00 was seen in 22% of the patients, having a RCMLN of 20%. In GB. the Sv>2. 00 was seen in 78% of the patients with a RCMLN of 73%. ②The Sv was negatively corredated with prognosis in GA. the Sv averged 1. 75±0. 503. while in GB. the figure was 3. 202±l. 136. there were 72 cases having a Sv≤2. 00 and 92% had a 5 year survival. The Sv ≤2. 00 value being a safe one. There were 78 cases having a Sv>2. 50. and 92% died in one year and the Sv>2. 50 was a dangerous value. In this paper, our views were put forward about the Sv in relation to typing the growth patterns of squamous cell epithelial carcinoma of esophagus the Sv≤2. 00 represents a saft type, the Sv>2. 50 a dangerous types, and the type is at the junction of these two types falls into the commonborder type. Through the analysis of 8% of the cases. it was found that prognosis was influenced by other factors morphologicall. when the values of the Sv were identical with each other.