含镁极化液治疗急性心肌梗塞100例疗效分析

AMI WERE TREATED WITH POLARIZED SOLUTION WITH Mg^(2+) ANALYSIS OF EFFECT OF 100 CASES

本文采用含镁极化液治疗(极化液加25％硫酸镁5～10ml,每日1次,持续9～21天)急性心肌梗塞(AMI)100例,其中男75例、女25例,年龄最小31岁、最大80岁,痊愈92例、死亡8例。通过对其疗效分析,认为心肌缺血、梗塞时血清镁含量降低.严重影响心肌代谢及功能,静滴含镁极化液效果显著。其主要作用为:对抗儿茶酚胺,改善冠脉循环,保护缺血和再灌注心肌,缩小梗塞面积,通过改善钾钙代谢,稳定暎电位,延长不应期,预防、消除心律失常;促进前列环素合成,降低周围血管阻力,减轻心脏后负荷,预防、治疗泵衰竭。除并发严重呼衰、肾衰、出血倾向者外,含镁极化液可作为AMI的常规治疗措施。

100 cases of AMI patients were treated with the polarized solution (polarized solution+25% MgSO_4 5～10ml qd,9～21 days). Male:75 cases, female:25 cases,age:31～80 years old, fully recovered:92 cases,died:8 cases. We conclude from this article that Mg^(2+) is decreased in myocardium when it is ischemia and infarct, which influences myocardial metabolism and function remarkablly, the effect of the polaried solution in treating is marked. The main effect of the solution is anti-catecholamine, improving the coronary circulation, protecting ischmia reperfusion myocardial injury, lessening the infarct area; improving K^+and Ca^(2+) metabolism, stablizing the potential of cell membrane, prolonging the refarctory period, preventing and eliminating arrhythmia; promoting the composition of PGE_2, decreasing the resistance of peripheral vessels, lowering the after-load of the heart, preventing and treating pump failure. This solution could be used routinly in AMI patients except accompanied by severe respiratory failure, kidney failure and bleeding tendency.