巨噬细胞激活剂在巨噬细胞毒性因子(Mφ-CF)产生中的作用

ROLE OF ACTIVATING AGENTS IN THE PRODUCTION OF M-DERIVED CYTOTOXIC FACTOR(Mφ-CF)

本文探讨厂 M激活剂(主要是 LPS 和 MAF 对 M-CF 产生的作用。研究结果表明:①在实验所用激活剂的作用下;M均可产生一定活性 CF,以 LPS 和 MAF 效果最好;②高活性 M-CF 的产生有赖于环境中激活剂的长期存在;③不同来源的 M(脾脏 M,腹腔炎症M和固有 M)在激活剂作用下,产生的 CF 活性均有增高,膜表面 C3b 和 Fc 受体活性也增强。

We observed the effect of M activating agents on M-CF production.The results showed that M could produce CF in the presence of stimuli we used,and LPS and MAF could aug- mente M producing CF with a high activity;CF production needed for the continuous presence of M activating agents;M from different anatomically site not only could produce CF in the presence of LPS,but also the activity of C3b and Fc receptors on M membrane were augmented.