维生素E对甲基苄基亚硝胺诱发小鼠前胃肿瘤的影响

THE EFFECT OF VITAMIN E ON THE OCCURRENCE OF FORE-STOMACH TUMOUR CAUSED BY N-NITROSO-N-METHYLBENZYLAMINE(NMBzA)IN MICE

我们研究了维生素 E(Vit E)对甲基苄基亚硝胺(NMBzA)诱发昆明种小鼠前胃肿瘤的影响。以 NMBzA 隔日10mg/kg 体重灌喂10次诱发肿瘤,另隔日灌喂5mg/只 VitE 至5个月,实验 VitE 的防癌作用。结果表明:与阳性对照组比较,VitE 能降低前胃四肿瘤的发生率和癌变率,但无统计学差异(P>0.05,P>0.05),可能因 VitE 用量较小,未能显现出防癌效果。该实验可为人类食管癌的预防提供参考。

The effect of vitamin E on the occurrence of fore-stomach tumour induced by NMBzA in Kunming breeding mice was studied.The mice was intubated NMBzA 10mg/kg wt every other day for 10 times to induce tumour of the fore-stomach.On the interval day,animals were intubated with 5mg of vitamin E(VitE)in 5 months,in order to research into the effect of cancer prevention of VitE. The results showed that VitE could decrease the rates of the occurrence and carcinological changes of fore-stomach tumour as compared with positive control;but no statistical difference was seen (P>0.05,P>0.05).Maybe the quantity of used VitE was smaller,the effect of prevent carcinogen- esis from VitE was not displied.This experiment provide reference for the prevention of human esophageal cancer.