氧合温血心麻液持续灌注对心肌抗氧化酶活性的影响

EFFECT OF WARM OXYGENATED BLOOD CARDIOPLEGIA CONTINUOUS PERFUSION CORONARY ARTERY ON MYOCARDIUM ANTIOXIDANT ENZYME ACTIVITY

我们对10例体外循环手术病例采用氧合温血心麻液持续灌注心肌停跳,观察其对心肌抗氧化酶活性的影响,同时观察了心肌组织过氧化脂质的变化及血清肌酸磷酸激酶,乳酸脱氢酶的变化。研究结果表明采用氧合温血心麻液持续灌注后心肌抗氧化酶活性均有不同程度升高,心肌过氧化脂质稍降低,血清肌酸磷酸激酶及乳酸脱氢酶无明显变化。结果提示氧合温血心麻液持续灌注能保护心肌抗氧化酶活性,保护心肌细胞结构,防止心肌缺血及再灌注损伤。

We observed that the effect of warm oxygenated blood cardioplegia induction heart arrest on myocardium antioxidant enzyme activity in 10 patients who suffered from extracorporal circulation operation.We also tested the serum level of CPK,LDH and LPO during operation.The results showed that after warm oxygenated blood cardioplegia perfusion coronary artery myocardium antioxidant enzyme activity increased and the serum level of LPO,GPK and LDH were stable.The results indicated warm oxygenated blood cardioplegia can protect myocardium antioxidant activity and myocardium cell structure.This method can prevent from myocardium ischcmia and reperfusion injury.