长期血液透析患者血清载脂蛋白(a)表型及其它脂质的测定分析

Determination and analysis of apolipoprotein(a) phenotype and other lipids in renal failure with hemodialysis patients

HD治疗的患者常导致脂质代谢异常,并有较高的心脑血管疾病发病率.我们检测了经HD治疗后72例慢性肾衰患者(CRF)血清载脂蛋白(a)及其它脂质水平,分析了脂质异常的原因。经与190例健康人比较,发现载脂蛋白(a)表型在HD组和对照组中的整体构成比差异不大(P>0.5),但表型B在HD组中出现的频率明显高于对照组(P<0.05).另外,HD组甘油三酯和脂蛋白(a)浓度亦明显高于对照组(P<0.001),高密度脂蛋白胆固醇和载脂蛋白Al,浓度明显低于对照组(P<0.001),其它脂质在两组间的差别不显著(P>0.5)。

Patients with renal failure (RF) on hemodialysis(HD) therapy are at significantly increased risk of cardio-cerebrovascular disease (CCVD). We determined the alteration of apolipoprotein(a) phenotypes and other lipids in 72 RF patients with HD treatment and compared with 190 controls. The result showed that phenotype B in patients were remarkably higher than those controls (P < 0. 05 ), the serum triglycerides and lipoprotein (a) concentration are significantly elevated in patients(P<0. 001). Inversly.the serum HDL-ch and apo Al levels were remarkably lower than controls(P<0. 001). The other lipids levels are no different(P>0. 5).