肾病综合征患儿血清补体抗御免疫复合物致病性的研究

Study on prevention of immune complex pathogenicity by serum complement of children with nephrotic syndrome (NS)

作者测定了60例肾病综合征患儿血清补体抑制免疫复合物沉淀和溶解免疫复合的能力(ICPIC,CMSC).临床分析表明,单纯性肾病患儿血ICPIC和CMSC无明显异常,而肾炎性肾病、乙肝性肾炎、紫癜性肾炎患儿则显著下降.肾脏病理分析表明,除微小病变型肾病无显著异常外,其它类型均有不同程度下降.此外,研究发现血ICPIC和CMSC可较好地反映肾病远期转归,而且反映肾脏病变活动性比血补体(CH_(50),C_3和C_4)和血循环免疫复合物敏感.

The serum complement mediated immune complex solubilizing capacity (CMSC) and immune complex precipitation inhibition capacity (ICPIC) of 60 children with NS were measured. The clinical analysis showed that the level of ICPIC and CMSC was not significantly abnormal in children with simple NS, and markedly decreased in those with nephritic NS,HBV associated nephritis and purpuric nephritis. The renal pathologic analysis showed that except for minimal change NS, the level of ICPIC and CMSC was variously reduced in children with mesangial proliferative glomerulonephritis, focal segmental glomerulosclerosis and membrane nephropathy. The results also revealed that the level of ICPIC abd CMSC reflected long-term prognosis of diseases. These results suggested that except for minimal change NS and simple NS, there was decreased prevetion of immune complex pathogenicity by serum complement in majority of children with NS which was immune complex disease.