冬虫夏草对肾毒性损害大鼠尿及肾组织中 EGF 变化的影响

Effect of Cordyceps Sinensis on the alteration of EGF in renal tissue and urine in gentamicin nephrotoxicity

本研究动态观察了冬虫夏草对肾毒性损害大鼠尿及肾组织中 EGF 变化的影响。实验结果表明,在急性肾毒性损害早期,肾组织中 EGF 出现重新分布,尿 EGF 排泄减少,而随着損害的修复,尿及肾组织中 EGF 逐渐增加;冬虫夏草治疗组大鼠尿及肾组织中 EGF 升高较庆大霉素组明显,且高峰提前,与此平行,肾小管修复较早,肾功能恢复较快。提示冬虫夏草增加 EGF 的作用,可能是它加速小管修复,促进肾功能恢复的机理之一。

This study was carried out to observe the alteration of EGF in renal tissue and the amount of urinary EGF excretion in gentamicin toxicity rats with or without the supplementation of Cordyceps Sineasis (CS).Male SD rats were randomely divided into two groups.Each group recieved gentamicin 160mg/kg·Bw/day,ip×7 day.In adition gentamicn+CS group was adiministcred CS 1g/day p.o,×7 day and gentamicin group was given normel salin simultaneously.It was found that there were a redistribution of EGF in renal tubule and decrease of urinary EGF excretion during the acute phase of gentamicin toxicity.However the amount of identified in renal tubular cells and the excretion of EGF in urine increased progressively toward the recovery period of ARF.Interestingly,the changes of urinary EGF excretion,renal tubular regeneration and renal function recovery in gentamicin+CS group were more earlier and faster than that in gentamicin group.Our study suggested that CS might be by way of increasing urinary and renal tissue EGF to accelerate tubular repair and promote recovery of renal function.