癫痫病灶DNA含量和细胞周期的分布

DNA contents and cells periods in the epileptic focuses

提要本文报告用流式细胞仪测定16例不同癫痫病灶中DNA含量和细胞周期的变化情况。我们发现顽固性癫痫病灶中的DNA含量较低,其S期细胞的比例较少。结果提示DNA值与癫痫患者的临床过程关系密切。我们认为癫痫病灶DNA含量和S期细胞减少,可以解释为癫痫的病因之一。如果提高S期细胞的比例和DNA含量,或许能够达到治疗癫痫的目的。本文对DNA含量与病理之间的关系也进行了讨论。

The DNA contents and cells periods in 16 resected epileptic focuses were determined by Flow Cytometric Analysis. The contents of DNA and cells in S period in untreatable epileptic focal tissues were lower than in tumorous epileptic focal tissues. The results of this study indicated that DNA values correlated well with the clinical course of patients with epilepsy. The lower values of DNA in epileptic focuses may be one of the mechanisms of epilepsy. Perhaps the untreatable epilepsy will be treated by the rising DNA content. The DNA contents and cells periods were briefly discussed in this paper.