血清甲状腺激素水平检测在肝炎后肝硬化中的临床意义

Clinical significance of serum thyroid hormone determination of posthepatitic cirrhosis

对45例肝炎后肝硬化及40例健康对照者进行血清甲状腺激素(T_3、rT_3、T_4)检测。结果发现肝硬化患者血清T_3、T_4水平明显低于正常对照者(P<0.05),失代偿期肝硬化患者降低更为明显(P<0.01),而rT_3水平明显高于对照者(P<0.01),同时发现T_3、T_4降低,rT_3升高与肝功能异常程度(A、A/G、SB、ch)显著相关(P<0.05或P<0.01),与SGPT、AKP不相关。提示血清甲状腺激素水平检测对病情的判断及预后估计有重要的临床意义.

Serum thyroid hormone( T_3, rT_3 and T_4) were determined in 45 cases of posthepatitic cirrhosis and in 40 healthy subjects. The results showed that se- rum T_3 and T_4 of patients with posthepatitic cirrhosis were lower than those of the control group(P<0.05). The drop of T_3 and T_4 in patients with cirrhosis in decompensation period was more obvious (P<0.01) but rT_3 was higher than that in the control group(P<0.01). The drop of T_3 and T_4, and raise of rT_3 were found to be significantly correlated with degrees of hepatic dysfunction(P<0.05 or P<0.01), but not correlated with SGPT and AKP. It is suggested that the serum thyroid hormone determination have clinical signifi- cance in the diagnosis and prognosis of the disease.