摘要
本实验用体外培养的人唾腺腺样囊性癌ACC—2细胞研究了钙拮抗剂维拉帕米(VP)对米托蒽醌(DHAD)细胞毒性的增效作用。发现无毒剂量的VP能够显著增强DHAD对ACC-2细胞增殖及其集落形成的抑制。实验结果,按两药合用效应评价方法判断,显示两药合用时的细胞存活分数SF值为0.179,明显小于两药单用时的细胞存活分数SF值乘积0.3l,表明两药合用对ACC—2细胞的细胞毒有协同效应。
The combined effect of verapamil and DHAD on the growth of human adenoid cystic carcinoma cell line (ACC-2) in vitro was investigated. In combination, VP and DHAD had synergistic inhibitory effect. VP enhanced the cytotoxicity of DHAD in ACC - 2 cells and significantly inhibited the cell proliferation. VP also potentiated the inhibitory effect of DHAD on colongenic ability of ACC - 2 cells, suggesting it enhance the cytocidal effect of DHAD on human adenoid cystic carcinoma.
出处
《上海口腔医学》
CAS
CSCD
1993年第1期18-21,59,共5页
Shanghai Journal of Stomatology
