牙周病患者唾液中6-K-PGF_(lα)的测定

The relationship between periodontal diseases and prostacyclin in saliva of periodontal patients by RIA

作者对15例牙周炎患者,10例龈炎患者和10名健康人(作对照),用放免测定法测定唾液中6-K-PGF_10含量。结果表明人唾液中6—K—PGF_(?)含量从健康对照组、龈炎组到牙周炎组呈递增趋势,各组间有显著差异,牙周炎为健康人的3.6倍,龈炎为健康人的2.6倍,且成人牙周炎与青少年牙周炎有显著差异,与临床牙周指数相关,说明6-K-PGF_10在牙周病的发病中有重要意义。提示测定唾液中6-K-PGF_(?)含量可能反映牙周病的严重程度。

The purpose of this investigation was to measure the changes of Prostacyclin (PGT2) occuring in gingivitis and periodontitis. Fifteen cases of periodontitis, ten cases of gingivitis and ten cases of healthy participated in this study, Saliva was taken before treatment, Prostacyclin in saliva was measured by ra-dioimmunoassay (RIA). The results showed that prostacyclin of human saliva is increased from healthy gingivitis to periodontitis. There is a statistical difference between groups,6-k- PGFlα in saliva of periodontitis is 3. 6 folds of healthy. Gingivitis is 2. 6 folds of healthy. There is also a significant difference between adult periodontitis Our findings suggested that prostacyclin may play an important role in etiology of periodontal disease. Measured 6-k-PGFlα in saliva may indicate the severity of periodontal disease.