涎腺恶性肌上皮瘤的组织学及免疫组织化学研究

Histolgical and immunohistochemical study of malignant myoepithelioma of salivary glands

作者分析了12例涎腺恶性肌上皮瘤的组织学及免疫组织化学特征。结果表明:该瘤镜下主要有4种不同的组织学类型:(1.)透明细胞增生为主,可伴有角化珠形成;(2)梭形细胞增生为主,伴有或不伴有粘液样区域;(3)瘤细胞为浆细胞样,弥漫分布;(4)瘤细胞为立方形,构成腺样结构.免疫组织化学染色显示该瘤对抗肌动蛋白(actln)、肌球蛋白(myosin)、胶质纤维酸性蛋白(GFAP)及S一100蛋白均呈不同程度的阳性反应。因此作者认为:运用这4种抗体的染色有助于该瘤的病理诊断及鉴别诊断。

Histological and immunohistochemical feartures of 12 cases of malignant myoepithe-lioma of the slivary glands were studied. There were 4 major histologic types in the tumor tissues: (1)clear tumor cells proliferated mainly with or without keratin peral; ( 2 ) spindle shaped tumor cells proliferated mainly with or without mucoid regions; (3)plasmacytoid(hyaline ) tumor cells were arranged in adenoid configurations. In the immunohistochemical studies,the tumor cells were positive for actin i myosin; glial, fibrillary, acidic, protein. (GFAP);S-100 protein antibodies. The authors consider that the application of the above-mentiones antibodies may assist in the differentiated diagnosis of malignant myoep-ithlioma.