进展期胃癌预后有关因素的探讨

STUDY ON PROGNOSTIC FACTORS IN ADVANCED GASTRIC CARCINOMA

本文收集1986年11月以前经手术切除的胃癌40例,按五年生存期分为 A、B 两组(≥5年为 A 组,<5年为 B 组)。从粘液组织化学[AB(PH2.5)/PAS、HID/AB(PH2.5)]、免疫组织化学(CEA、ER 的表达)及核形态测量参数等方面探讨其与组织学类型及预后的关系。结果发现即使是低分化型癌,分泌酸性粘液者预后较好;ER 阳性者较阴性者好;而 CEA 表达与预后无关;核形态测量在高分化型癌与预后有关,低分化型癌 B 组的细胞核具有异型性,但核面积与核周长的值均小于 A 组,有参考价值。

Forty cases of advanced gastric carcinoma treated by curaive resection were followed up and stratified into group A,those who survived more than five years,and group B,survival for less than five years.Using mucin histochemistry AB,(PH2.5)/PAS,HID/AB(PH2.5),immunohistoc- hemistry(expression of CEA and ER)and nuclear morphometry(nuclear area,perimeter and maximal diameter)as parameters,the prognostic factors were studied.The results indicated that low differentiated(LD)gastric carcinoma secreting acidic mucin shows a better prognosis than the high differentiated(HD)one.The prognosis of gastric cancer with positive ER is better than that of ER negative,but the expression of CEA has no significant impact on prognosis.Nuclear morphometry of high differentiated carcinoma is related to prognosis.LD carcinoma present nu- clear pleomorphism.The value of nuclear morphometry is lower in group B than that of group A,it has some significance for reference.