摘要
用硅胶柱层析法从茯苓Poria cocos(Schw.)Wolf的干燥菌核中分离出一种三萜类有机酸,根据理化性质及光谱数据确定为茯苓酸(Pachymic acid),抗肿瘤实验表明茯苓酸对小鼠Sarcoma 180抑制率达62.8％,茯苓中的水溶性低分子量化合物无抗肿瘤活性。
Lower molecule compounds frationated from the mycelia of Poria cocos were evaluated for antitumor activity against mouse tumor. The water-soluble fration of ethanol extract was found to be inactive against intraperitoneally implanted Sarcoma180. The chloroform-soluble fraction of ethanol extract and pachymic acid which has been isolated from Poria cocos and identified by physical properties and spectral data showed strong antitumor activity.
出处
《中国药物化学杂志》
CAS
CSCD
1993年第2期128-129,131,共3页
Chinese Journal of Medicinal Chemistry
基金
国家中医药局青年科技基金
关键词
茯苓
茯苓酸
抗肿瘤活性
Poria cocos
Antitumor activity
Pachymic acid
