分娩前后酮病奶牛脂代谢指标的分析

STUDIES ON LIPID MOBILIZATION IN DAIRY COWS WITH KETOSIS BEFORE AND AFTER PARTURITION

1992年10月～1993年2月,从182头产犊前后的黑白花奶牛中筛选临床型酮病牛8头,亚临床酮病牛30头分别测定其血清中酮体(KB)、糖(Glu)、游离脂肪酸(FFA)、胆固醇(CT)、磷脂(Pho)、高密度脂蛋白胆固醇(HDL-CT)、谷草转氨酶(GOT)、乳酸脱氢酶(LDH)、胰岛素(Ins)、胰高血糖素(Glucagon)等。结果表明,酮病牛脂肪动员呈单峰规律,动员盛期延长。临床型酮病牛,主要表现高酮血和低血糖症并伴有肝功能障碍,GOT 和LDH 呈高值,分别为60±9.7u/L 和534.6±11.86u/L;CT、Pho、HDL-CT 值显著低于亚临床酮病牛。耐糖试验结果表明:临床型酮病牛经给糖后15min 对 Glu 的吸收和利用仍缓慢,而 FFA 则很快下降至正常值,有快速缓解脂动员倾向;对 Ins 的应答,呈弱反应,而对 Glucagon 的应答则略有下降。

Eight cows suffered from clinical ketosis and 30 cows suffered from subclinical ketosis were selected from182 cows before and after parturition.The serum ketone,free fatty acids(FFA),phospholipids(PL),cholesterol(CT),high density lipoprotein-cholesterol(HDL-CT),blood glucose,lactate dehydrogenase(LDH),aspartatetransaminase(GOT),insulin and glucagon were measured.Tne results indicated that ketosis cows showed systematic lipidmobilization with extending peak duration.High ketonemia,low blood glucose and hepatic dysfunction were found inclinical ketesis cows.The levels of GOT and LDH were high at 60±9.7u/L and 534.6±11.86u/L repectively.Thevalues of HDL-CT,CT and Pho in clinical ketosis cows were lower than those in subclincal ketosis cows.For clinicalketosis cows,slow uptake and utilization of glucose were found by glucose durability test.The FFA value was rapidlydecreased to normal,indicating that glucose tend to moderate lipid mobilization.Low response to insulin and slightlydecrease in glucagon were found in clinical ketosis cows.